Sleeve gastrectomy causes gallstones (stones form faster after sleeve/rapid weight loss).
Original statement
وانت تخين وخسيت بيجي لك حصوه وانت عامل تكميم بيجي لك الحصوه اسرع
verbatim according to source. Translation by the project; the Arabic wording is authoritative.
Translation
Sleeve gastrectomy causes gallstones (stones form faster after sleeve/rapid weight loss).
Origin
- Source status
- Video transcript (own words)
- Attribution
- Elawady (machine transcript)
- Video
- Dr.D Clinics - Diaa Al Awady is live!ايه هو ال HDL⧸ LDL⧸ Chylomicrons (Open source)
- Published
- 5 April 2025
- Timestamp
- 0:25:45 (location in the original video’s automatic YouTube caption track; confirms where the words occur, not who speaks)
- Attribution uncertainty
- Archive transcript (YouTube CC or AI-generated); wording may contain transcription errors; no timestamps available.
- Claimed mechanism
Rapid weight loss after sleeve.
- Claimed health effect
Gallstones.
- Population concerned
Sleeve patients
- Geographic restriction by Elawady
none found
Diverging source versions
- Source status
- Video transcript (own words)
- Attribution
- Elawady (machine transcript)
- Video
- اتفرجوا عالبودكاست ده وقولولي رأيكوا عشان انزلكوا الحلقه التانيه منه (Open source)
- Published
- 9 April 2026
- Timestamp
- not available (transcript has no timings)
- Attribution uncertainty
- Archive transcript (YouTube CC or AI-generated); wording may contain transcription errors; no timestamps available.
- Source status
- Video transcript (own words)
- Attribution
- Elawady (machine transcript)
- Video
- الخوف حقيقه ام سراب. أضرار التكميم. بين الحقيقه والسراب (Open source)
- Published
- 19 November 2025
- Timestamp
- not available (transcript has no timings)
- Attribution uncertainty
- Archive transcript (YouTube CC or AI-generated); wording may contain transcription errors; no timestamps available.
Scientific assessment
Mostly true – Correct at its core, but with limitations or minor inaccuracies.
Certainty of evidence: moderate – Further research may still affect the assessment.
1. What was claimed?
Gallstones after sleeve.
2. What is demonstrably correct?
Correct: gallstone formation after bariatric surgery, including sleeve, is a recognized complication; UDCA prophylaxis reduced gallstone formation (OR 0.25), symptomatic disease (OR 0.29) and cholecystectomy (OR 0.33) in RCTs including sleeve patients (I-BAR-12).
3. What is wrong or exaggerated?
'Always' (دايما) overstates it; many patients do not form stones.
4. What remains unclear?
Exact incidence after sleeve compared with equal non-surgical weight loss; the Egyptian trial abstract contains internally inconsistent numbers.
5. Which studies support it?
I-BAR-12; Egyptian RCT (I-BAR-136): gallstones in about 22% within a year without prophylaxis vs 6.5% with UDCA; most stone formers had sleeve.
6. Which studies contradict it?
None against the direction; gallstone risk after sleeve is not higher than after bypass (I-BAR-137).
7. What applies to Germany and Europe?
Most key data are European (Sweden SOS/SOReg, Finland SLEEVEPASS, Switzerland SM-BOSS). European and international society guidelines consider bariatric surgery for severe obesity with lifelong follow-up.
8. What is known about Egypt?
No Egypt-specific outcome data were identified in this review. Elawady states in a transcript that sleeve gastrectomy is very widely performed in Egypt ('مصر كلها بتعملها'); the procedure-specific risks (reflux, deficiencies) apply wherever it is performed, and follow-up quality (supplements, endoscopy, mental-health screening) determines part of the risk.
9. What practical conclusion is appropriate?
Gallstone prevention is part of bariatric aftercare in many centres.
Assessment details
- Rationale for certainty of evidence
Gallstone formation after bariatric surgery (including sleeve) is established enough that 11 RCTs tested and confirmed prevention with UDCA.
- Source quality
Elawady's statement matches established surgical knowledge.
- Regional transferability
Applicable.
- Individual exceptions
Not every patient forms stones; UDCA prophylaxis reduces risk by about 75%.
- Regional scope of the claim
- general (biological/medical)
- Last reviewed
- 26 October 2026 provisional
Scientific evidence in detail
Scientifically well supported – The claim agrees with consistent, high-quality evidence.
Research question: Does sleeve gastrectomy (via rapid weight loss) increase gallstone formation?
Research question in detail (PICO)
- Population
- Adults after sleeve gastrectomy
- Intervention or exposure
- Sleeve gastrectomy / rapid weight loss
- Comparison
- Placebo prophylaxis arm; bypass; non-surgical weight loss
- Geographic scope
- universal biology
- Outcomes
- Incident gallstones
- Symptomatic gallstone disease
- Cholecystectomy
Study results as reported by the authors. Our assessment follows below.
What speaks for the claim?
Egyptian trial: gallstones after obesity surgery
Talha et al.. Surg Endosc 2020 · PMID 31858245 · DOI 10.1007/s00464-019-07323-7 Randomised controlled trialabstract checkednewly addedEgyptian RCT: without prophylaxis about 22% formed gallstones within a year; most stone formers had sleeve.
- Actual result
- 22% placebo vs 6.5% UDCA; NNT 6.
- Methodological quality
- moderate (RCT with reporting inconsistencies)
- Relevance
- direct, regional
- Limitations
- Abstract numbers inconsistent
Preventing gallstones after weight-loss surgery
Mulliri A et al.. J Gastroenterol 2022 · PMID 35704084 · DOI 10.1007/s00535-022-01886-4 Meta-analysisabstract checkedMeta-analysis of RCTs: UDCA markedly reduces gallstones after bariatric surgery including sleeve.
- Actual result
- OR 0.25 (0.21-0.31).
- Methodological quality
- high
- Relevance
- indirect (implies substantial baseline risk)
- Limitations
- Prevention trials
What speaks against the claim?
Meta-analysis: gallstones after sleeve vs bypass
Silva-Chavez et al.. Obes Surg 2025 · PMID 41251897 · DOI 10.1007/s11695-025-08388-1 Meta-analysisabstract checkednewly addedMeta-analysis: gallstones after both procedures; short-term risk lower after sleeve than bypass.
- Actual result
- OR 0.68 (0.53-0.88), fragile.
- Methodological quality
- moderate
- Relevance
- limits a sleeve-specific excess vs bypass
- Limitations
- Heterogeneous
What does the overall evidence say?
Editorial assessment based on the studies above – not itself a study result.
Which position is better supported?
Gallstones commonly form after sleeve and other bariatric operations because of rapid weight loss; not everyone is affected and prophylaxis prevents most.
Why some studies weigh more
RCT placebo arms give direct incidence; meta-analysis of RCTs shows preventability.
Is a causal relationship established? Yes, established Rapid weight loss is a known cause of cholesterol gallstones.
Remaining uncertainty
Exact sleeve incidence vs equal non-surgical weight loss.
Justified conclusion
Correct; "always" overstated.
Why do studies seem to disagree?
Sleeve vs bypass comparisons are inconsistent and sensitive to one large study; both procedures raise risk.
Does this depend on the country?
- General biological effects
- Universal.
- Eating habits
- Not applicable (surgical procedure, not a food).
- Origin of the food
- Not applicable (surgical procedure, not a food).
- Contaminants
- Not applicable (surgical procedure, not a food).
- National production conditions
- Not applicable.
- Legal rules
- Not applicable.
- Actual monitoring data
- Egyptian RCT (I-BAR-136) directly relevant.
A regional difference that changes the conclusion is not supported by robust data.
Statistical re-check
- ARR/NNT and internal consistency – ARR 15.5 points, NNT 6.5 (reported 6); overall incidence 9.7% inconsistent with arm rates unless groups very unequal; "RR is 3.4%" invalid. recalculated
Certainty of the overall evidence (GRADE, simplified)
- Main outcome
- Gallstone formation after sleeve/rapid weight loss
- Starting level
- high (randomised trials)
- Reasons for downgrading
- indirectness (mixed procedures)
- Result
- moderate
Simplified assessment by a single reviewer, following the GRADE approach; not a formal GRADE panel. GRADE rates the body of evidence for one outcome, not individual studies.
Search strategy
Documented literature searches for this review (search strings in the original database syntax).
| Database | Date | Search | Looking for | Hits | Included |
|---|---|---|---|---|---|
| Europe PMC | 26 October 2026 | (TITLE:"gallstone*" OR TITLE:"cholelithiasis" OR TITLE:"cholecystectomy" OR TITLE:"gallbladder") AND (TITLE:"sleeve gastrectomy" OR TITLE:"bariatric") AND (PUB_TYPE:"Meta-Analysis" OR TITLE:"meta-analysis" OR TITLE:"incidence" OR TITLE:"nationwide" OR TITLE:"randomized") AND PUB_YEAR:[2017 TO 2026] | both directions | 43 | |
| PubMed | 26 October 2026 | (gallstone*[ti] OR cholecystectomy[ti] OR gallbladder disease[ti]) AND (bariatric[ti] OR obesity surgery[ti] OR sleeve gastrectomy[ti]) AND (controls OR nonoperated OR non-operated OR matched OR Swedish Obese Subjects) | supporting evidence | 46 |
Open questions
Sleeve-specific incidence in Egypt with ultrasound follow-up.
How deeply was this checked?
3 linked studies: 0 checked in full text (0 of them with a structured risk-of-bias assessment), 3 on the basis of the abstract, 0 bibliographically only. No formal assessment with two independent reviewers and no independent human expert review has taken place yet.
Last scientific review: 26 October 2026
History of the verdict
- 25 October 2026 · Phase 1 · Initial assessment: Mostly true (moderate)
- 26 October 2026 · Phase 4 (systematic evidence review) · Re-examined with extended evidence; verdict unchanged: Mostly true (moderate)
Unchanged (“Mostly true”, moderate). Egyptian RCT adds direct regional incidence data.
New sources: I-BAR-136 I-BAR-137
In plain language
Elawady said that gallstones form faster after sleeve gastrectomy. This is correct. Rapid weight loss after surgery makes gallstones more likely, and trials show that a bile-acid medicine can prevent many of them. Not every patient gets stones, however.
Studies on this claim
Studies supporting the claim (2)
-
Preventing gallstones after weight-loss surgery
Mulliri A et al.. J Gastroenterol 2022 · PMID 35704084 · DOI 10.1007/s00535-022-01886-4Meta-analysisindependent cross-checkabstract checkedA bile-acid drug cut new gallstones by about 75% after surgery, including sleeve.
Sleeve gastrectomy causes gallstones (stones form faster after sleeve/rapid weight loss).
Does the study support the specific claim? Partly · Methodological quality: moderate · Certainty of evidence: see overall assessment of the claim
Original publication · Scientific details
Study explained simply
- What did the researchers want to find out?
Gallstone prevention
- How was the study done?
Meta-analysis of RCTs
- How many people, animals or samples were studied?
3474
- What was actually found?
UDCA effective
- How large was the observed effect?
OR 0.25
- What do the results mean in everyday life?
Gallstones after surgery are expected and preventable
- What are the study's limitations?
Incidence not in abstract
- What does it say about Elawady's specific claim?
Supports that sleeve can lead to gallstones
- Do the results apply to Germany and Europe?
Applicable
- What can explicitly not be concluded from this study?
Absolute risk
-
Egyptian trial: gallstones after obesity surgery
Talha et al.. Surg Endosc 2020 · PMID 31858245 · DOI 10.1007/s00464-019-07323-7Randomised controlled trialindependent cross-checkabstract checked★ key studyWithout preventive medicine, about 22 in 100 patients formed gallstones within a year; a bile-acid medicine lowered this to about 6 in 100.
Gallstones in 22% without prophylaxis; most stone formers had SG.
Does the study support the specific claim? Yes · Methodological quality: moderate · Certainty of evidence: see overall assessment of the claim
Original publication · Scientific details
Study explained simply
- What did the researchers want to find out?
Gallstones and UDCA
- How was the study done?
RCT
- How many people, animals or samples were studied?
1,432
- What was actually found?
22% vs 6.5%
- How large was the observed effect?
NNT 6
- What do the results mean in everyday life?
Gallstones are common after rapid weight loss and largely preventable
- What are the study's limitations?
Inconsistent numbers in abstract
- What does it say about Elawady's specific claim?
Supports the claim
- Do the results apply to Germany and Europe?
Egypt
- What can explicitly not be concluded from this study?
Exact sleeve rate
No study in this group is marked as key.
Studies contradicting or limiting the claim (0)
No studies in this group.
Studies with mixed or unclear results (1)
-
Meta-analysis: gallstones after sleeve vs bypass
Silva-Chavez et al.. Obes Surg 2025 · PMID 41251897 · DOI 10.1007/s11695-025-08388-1Meta-analysisindependent cross-checkabstract checkedGallstones formed after both operations; in the short term they were somewhat less common after sleeve.
Gallstones after both; SG not higher than RYGB (OR 0.68, fragile).
Does the study support the specific claim? Partly · Methodological quality: moderate · Certainty of evidence: see overall assessment of the claim
Original publication · Scientific details
Study explained simply
- What did the researchers want to find out?
Gallstones SG vs RYGB
- How was the study done?
Meta-analysis
- How many people, animals or samples were studied?
195,665
- What was actually found?
OR 0.68
- How large was the observed effect?
OR 0.68
- What do the results mean in everyday life?
Both operations raise gallstone risk
- What are the study's limitations?
Fragile
- What does it say about Elawady's specific claim?
Partly supports
- Do the results apply to Germany and Europe?
Applicable
- What can explicitly not be concluded from this study?
Risk vs no surgery
No study in this group is marked as key.
Regional context
Germany / EU
Most key data are European (Sweden SOS/SOReg, Finland SLEEVEPASS, Switzerland SM-BOSS). European and international society guidelines consider bariatric surgery for severe obesity with lifelong follow-up.
Egypt
No Egypt-specific outcome data were identified in this review. Elawady states in a transcript that sleeve gastrectomy is very widely performed in Egypt ('مصر كلها بتعملها'); the procedure-specific risks (reflux, deficiencies) apply wherever it is performed, and follow-up quality (supplements, endoscopy, mental-health screening) determines part of the risk.
What applies in my country?
General scientific assessment
Mostly true Correct: gallstones are a recognized consequence of sleeve and rapid weight loss.
This statement concerns biological or medical relationships. The scientific assessment above applies regardless of the country; country-specific food data do not change it.
References
- Ursodeoxycholic acid for the prevention of gallstones and subsequent cholecystectomy after bariatric surgery: a meta-analysis of randomized controlled trials.. Mulliri A et al.. J Gastroenterol 2022 · PMID 35704084 · DOI 10.1007/s00535-022-01886-4
- Cholelithiasis after bariatric surgery, incidence, and prophylaxis: randomized controlled trial.. Talha et al.. Surg Endosc 2020 · PMID 31858245 · DOI 10.1007/s00464-019-07323-7
- Comparative Risk of Gallstone Formation After Sleeve Gastrectomy and Roux-En-Y Gastric Bypass: A Systematic Review and Meta-Analysis.. Silva-Chavez et al.. Obes Surg 2025 · PMID 41251897 · DOI 10.1007/s11695-025-08388-1